|Reactivity||Human, Mouse, Rat|
|Calculated MW||46719 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~56 kDa band in samples from human, mouse and rat origins. Reactivity to other species has not been tested.|
|Other Names||BCL2L13 , Q9BXK5 , BCL-RAMBO , MIL1|
|Formulation||100 µg (0.2mg/ml) affinity purified rabbit anti-Bcl-rambo polyclonal antibody in phosphate-buffered saline (PBS) containing 0.1% BSA, 30% glycerol, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Bcl-Rambo Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May promote the activation of caspase-3 and apoptosis.|
|Cellular Location||Mitochondrion membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Bcl-rambo shares the common structural characteristics with other members of the anti-apoptotic Bcl-2 family members, but differs from them at its C-terminus, where a 250 amino acid sequence proceeds the membrance anchor region. It also differs from other pro-apoptotic Bcl-2 family members in that it membrane anchor C-terminus region is responsible for its apoptotic activity, not its Bcl-2 homology motifs.
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