|Reactivity||Human, Mouse, Rat|
|Calculated MW||64470 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Other applications have not been tested. The antibody recognizes ~65 kDa band in samples from human, mouse and rat origins. A cleavage fragment (~45 kDa) can also be detected in apoptotic samples. Reactivity to other species has not been tested.|
|Other Names||BIN1 , AMPH2 , amphiphysin-like , MGC10367 , DKFZp547F068 , AMPHL , SH3P9|
|Formulation||100 µg (0.2mg/ml) immunoaffinity purified rabbit anti-Bin-1 polyclonal antibody in phosphate-buffered saline (PBS) containing 0.1% BSA, 30% glycerol, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Bin1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Isoform 1 is expressed mainly in the brain. Isoform 2 is widely expressed|
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Provided below are standard protocols that you may find useful for product applications.
BIN-1 is a tumor suppressor protein that was identified in a genetic screen for proteins that interact with the MCY oncoprotein. BIN-1 inhibits the oncogenic activity of MYC, possibly thro µgh activating or facilitating apoptosis. BIN is a short-lived protein with a half-life of about 2 hours.
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