|Calculated MW||21973 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate can be used as positive controls. The antibody recognizes 21 kDa Bcl-B from samples of human and rat origins. Reactivity to other species has not been tested.|
|Other Names||Bcl2-L-10, Diva|
|Formulation||100 µg (0.5 mg/ml) Protein A affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Bcl-B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.|
|Cellular Location||Mitochondrion. Nucleus membrane|
|Tissue Location||Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
Bcl-B (also called Bcl2-L-10) is a novel anti-apoptotic member of the Bcl-2 family. Bcl-B is closest in amino acid sequence homology to Boo protein. It contains four Bcl-2 homologs. Bcl-B mRNA is widely expressed in adult human tissues. The Bcl-B protein binds to Bcl-2, Bcl-X(L), and Bax but not Bak. Bcl-B suppresses apoptosis induced by Bax, but not by Bak.
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