BIK Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q13323 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 18016 Da |
Gene ID | 638 |
---|---|
Application & Usage | Western blotting (2-6 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate can be used as positive controls. The antibody detects a ~17 kDa BIK in samples from human, mouse, and rat origins. A ~15 kDa cleavage fragment can also be detected |
Other Names | BCL2 interacting killer, Apoptosis inducer NBK, BIP 1, BIP, bik |
Target/Specificity | BIK |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) Protein A affinity purified rabbit anti-BIK polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | BIK Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BIK |
---|---|
Synonyms | NBK |
Function | Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. |
Cellular Location | Endomembrane system; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Note=Around the nuclear envelope, and in cytoplasmic membranes |
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Provided below are standard protocols that you may find useful for product applications.
Background
BIK is a member of Pro-apoptotic Bcl-2 family proteins. Altho µgh Bik lacks Bcl-2 homologus region, BH1 and BH2, BIK interacts with Bcl-2 and Bcl-xL. BIK has been shown to induce apoptosis by activating caspase-9.
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