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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   TUCAN/CARD8 Antibody   

TUCAN/CARD8 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2G2
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 48933 Da
Additional Information
Gene ID 22900
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects 47 kDa TUCAN in samples from human, mouse, and rat origins. Jurkat cell lysate, mouse small intestine and rat kidney tissue lysates can be used as positive controls.
Other Names DACAR , NDPP1 , TUCAN , CARDINAL , KIAA0955 , MGC57162 , DKFZp779L0366
Target/Specificity TUCAN
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) Protein A affinity purified rabbit anti-TUCAN polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5 BSA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsTUCAN/CARD8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CARD8
Synonyms KIAA0955, NDPP1
Function Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Cellular Location Cytoplasm. Nucleus
Tissue Location High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow
Research Areas
Citations (0)

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TUCAN (Tumor Up-regulated Card-containing Antagonist of Caspase-Nine) is a CARD (Caspase-Associated Recruitment Domains) containing protein that binds and suppresses activation of pro-Caspase-9 and found to be overexpressed in some types of cancers. TUCAN binds specifically to pro-caspase-9 and interferes with its interaction with Apaf-1, thereby suppressing apoptosis signaling in the mitochondrial/cytochrome c pathway.

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$ 245.00
Cat# ABV10538
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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