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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Calsenilin Antibody   

Calsenilin Antibody

Rabbit Polyclonal Antibody

  • WB - Calsenilin Antibody ABV10539
    Western blot analysis of Calsenilin expression with Jurkat cell lysate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y2W7
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 29231 Da
Additional Information
Gene ID 30818
Application & Usage Western blotting (2-6 µg/ml). However, the optimal conditions should be determined individually. The antibody detects ~30 kDa Calsenilin in samples from human, mouse, and rat origins. Jurkat cell lysate can be used as a positive control.
Other Names KCNIP3 , CSEN , DREAM , KCHIP3 , Calsenilin , KCHIP3 , MGC18289 , KChIP3
Target/Specificity Calsenilin
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) Protein A affinity purified rabbit anti-Calsenilin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.1% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCalsenilin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).
Cellular Location Cytoplasm. Cell membrane; Lipid-anchor Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000250, ECO:0000269|PubMed:15485870}
Tissue Location Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease
Research Areas
Citations (0)

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Calsenilin is also known as DREAM and KChlP3. Calsenilin interacts with presenilin-2, a protein involved in Alzheimer’s disease, to reverse presenilin mediated enhancement of calcium signaling. Calsenilin also has pro-apoptotic function, is a substrate for caspase-3, acts as a calcium regulated transcriptional suppressor, and interacts with A-type potassium channels.

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$ 245.00
Cat# ABV10539
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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