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Calsenilin Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9Y2W7 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29231 Da |
| Gene ID | 30818 |
|---|---|
| Application & Usage | Western blotting (2-6 µg/ml). However, the optimal conditions should be determined individually. The antibody detects ~30 kDa Calsenilin in samples from human, mouse, and rat origins. Jurkat cell lysate can be used as a positive control. |
| Other Names | KCNIP3 , CSEN , DREAM , KCHIP3 , Calsenilin , KCHIP3 , MGC18289 , KChIP3 |
| Target/Specificity | Calsenilin |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.2 mg/ml) Protein A affinity purified rabbit anti-Calsenilin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.1% BSA, 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Calsenilin Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KCNIP3 |
|---|---|
| Synonyms | CSEN, DREAM, KCHIP3 |
| Function | Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). |
| Cellular Location | Cytoplasm. Cell membrane; Lipid-anchor. Endoplasmic reticulum. Golgi apparatus. Nucleus. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. |
| Tissue Location | Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Calsenilin is also known as DREAM and KChlP3. Calsenilin interacts with presenilin-2, a protein involved in Alzheimer’s disease, to reverse presenilin mediated enhancement of calcium signaling. Calsenilin also has pro-apoptotic function, is a substrate for caspase-3, acts as a calcium regulated transcriptional suppressor, and interacts with A-type potassium channels.
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