|Calculated MW||73498 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody detects 73 kDa SGLT-1 from human samples and in a lesser extent from mouse and rat samples. A ~50 kDa cleavage fragment can also be detected in Jurkat cell lysate.|
|Other Names||SGLT 1 , SLC5A1 , Sodium glucose cotransporter 1 , D22S675 , NAGT|
|Formulation||100 µg (0.5 mg/ml) protein A affinity purified rabbit polyclonal SGLT-1 antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||SGLT-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed mainly in intestine and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally related substances across cellular membranes. Two families of glucose transporter have been identified: the facilitated diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters'. The SGLT1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells.
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