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Tom 40 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O96008 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37893 Da |
| Gene ID | 10452 |
|---|---|
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately. The antibody recognizes TOM40 in samples of human, mouse and rat origins. Reactivity to other species has not been tested. |
| Other Names | C19orf1 , D19S1177E , PER-EC1 , PEREC1 , TOM40 , p38.5 |
| Target/Specificity | Tom 40 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Tom 40 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TOMM40 |
|---|---|
| Synonyms | C19orf1, PEREC1, TOM40 |
| Function | Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein. Note=Associates with the mitochondria- associated ER membrane via interaction with BCAP31 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Translocase of the mitochondria Outer Membrane (TOM) is essential for protein import into mitochondria. TOM40 is synthesized in the cytosol and contains information for its mitochondrial targeting and assembly. It is delivered to the mitochondria in an ATP-dependent manner.
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