|Application ||WB, IP|
|Calculated MW||142695 Da|
|Application & Usage||Western blotting (1:500 – 1:2500) and immunoprecipitation. However, the optimal concentrations should be determined individually. The antibody recognizes the SLK of human and mouse origin. Reactivity to other species has not been tested.|
|Other Names||SLK, STE20-like Kinase, SLK, Sucrose nonfermenting like kinase, STK2, Serine/Threonine Kinase 2|
|Formulation||100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||SLK Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates apoptosis and actin stress fiber dissolution.|
|Tissue Location||Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
SLK (STE20-like kinase), also known as STK2 (serine/threonine protein kinase 2) or se20-9, is a member of the serine/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase Ste20, a protein involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades. Members of this subfamily include KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, GC kinase, HGK and SLK. SLK is a ubiquitously expressed protein that localizes to the cytoplasm and contains an N-terminal protein kinase domain, a central coiled-coil domain and a C-terminal ATH domain. SLK is activated through cleavage by caspase-3. SLK indirectly associates with microtubules and plays an important role in cellular stress, cell motility, cell death and cytoskeletal dynamics.
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