|Reactivity||Human, Mouse, Rat|
|Calculated MW||76094 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~95 kDa AAK1 in samples from human, mouse and rat origins. Reactivity to other species has not been tested. |
|Other Names||AAK-1, AAK1, AKK 1, AP2 associated kinase 1, Adaptor associated kinase 1|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||AAK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in transcriptional regulation.|
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Provided below are standard protocols that you may find useful for product applications.
AAK1 is a serine/threonine kinase that is tho µght to coordinate the recruitment of AP-2 to receptors containing tyrosine-based internalization motifs by phosphorylating the µ2 subunit. There is strong evidence that this protein is the endogenous mu 2 kinase and plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis.
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