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GPVI Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9HCN6 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36866 Da |
| Gene ID | 51206 |
|---|---|
| Application & Usage | Western blotting (0.5-4). However, the optimal conditions should be determined individually. The antibody recognizes ~58 kDa human GPVI. Jurkat cell lysate can be used as a positive control. |
| Other Names | Glycoprotein VI , glycoprotein 6, GP6 , gp6, gp 6, platelet collagen receptor |
| Target/Specificity | GPV |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | GPVI Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GP6 (HGNC:14388) |
|---|---|
| Function | Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2. |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass membrane protein |
| Tissue Location | Megakaryocytes and platelets. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glycoprotein VI (GPVI) is a membrane glycoprotein receptor for collagen found in platelets. GPVI plays an important role in platelet procoagulant activity and the formation of thrombin and fibrin.
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