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Neuropilin-1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P97333 |
| Other Accession | AAH60129 |
| Reactivity | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 103000 Da |
| Gene ID | 18186 |
|---|---|
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~100-130 kDa band of Neuropilin 1 in samples from human, mouse and rat, origins. A lower band ~50-70 kDa can also be detected, presumably to be the cleavage fragment of Neuropilin-1. Reactivity to other species has not been tested. |
| Other Names | CD304 , DKFZp686A03134 , DKFZp781F1414 , NRP , NRP1 , VEGF165R , neuropilin-1 |
| Target/Specificity | Neuropilin |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Neuropilin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Nrp1 {ECO:0000312|MGI:MGI:106206} |
|---|---|
| Synonyms | Nrp |
| Function | Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins (PubMed:26503042). Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage (By similarity). Binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR (By similarity). |
| Cellular Location | Mitochondrion membrane {ECO:0000250|UniProtKB:O14786}; Single-pass type I membrane protein. Cell membrane {ECO:0000250|UniProtKB:O14786}; Single- pass type I membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O14786} |
| Tissue Location | Nervous system. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Neuropilin 1 is a type 1 membrane-bound coreceptor to a tyrosine kinase receptor for both Vascular Endothelial Growth Factor and Semaphorin family members. Neuropilin 1 is invovled in axon growth and guidance, cell survival, migration, and invasion.
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Discontinued
Cat# ABV10667-30
Size:
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