|Reactivity||Human, Mouse, Rat|
|Calculated MW||86402 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 68 kDa and 86 kDa bands from samples of human, mouse, rat origins. Reactivity to other species has not been tested. |
|Other Names||mitofusin2, mitofusin 2, mitofusin-2, MFN2, CMT2A, CMT2A2, CPRP1, HSG, KIAA0214, MARF|
|Formulation||100 µg (0.5mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Mitofusin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.|
|Cellular Location||Mitochondrion outer membrane; Multi- pass membrane protein. Note=Colocalizes with BAX during apoptosis|
|Tissue Location||Ubiquitous; expressed at low level. Highly expressed in heart and kidney.|
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Mitofusin 2 (Mfn 2) is mostly expressed in the heart and muscle tissues. It is a transmembrane protein that mediates mitochondria fusion and plays a central role in the maintenance of mitochondrial morphology. A GTPase domain is required for the function of Mitofusin proteins. Mutations in Mfn2 can lead to Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system. Mfn2 may also be associated with obesity and/or apoptosis.
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