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Mitofusin 2 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O95140 |
| Other Accession | EAW71727 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86402 Da |
| Gene ID | 9927 |
|---|---|
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 68 kDa and 86 kDa bands from samples of human, mouse, rat origins. Reactivity to other species has not been tested. |
| Other Names | mitofusin2, mitofusin 2, mitofusin-2, MFN2, CMT2A, CMT2A2, CPRP1, HSG, KIAA0214, MARF |
| Target/Specificity | Mitofusin 2 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Mitofusin 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MFN2 {ECO:0000303|PubMed:12598526, ECO:0000312|HGNC:HGNC:16877} |
|---|---|
| Function | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:26214738, PubMed:28114303, PubMed:19889647). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein Note=Colocalizes with BAX during apoptosis |
| Tissue Location | Ubiquitous; expressed at low level. Highly expressed in heart and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Mitofusin 2 (Mfn 2) is mostly expressed in the heart and muscle tissues. It is a transmembrane protein that mediates mitochondria fusion and plays a central role in the maintenance of mitochondrial morphology. A GTPase domain is required for the function of Mitofusin proteins. Mutations in Mfn2 can lead to Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system. Mfn2 may also be associated with obesity and/or apoptosis.
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