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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PAK6 Antibody   

PAK6 Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q3ULB5
Other Accession AAI50755
Reactivity Human, Mouse, Rat, Pig, Horse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 74867 Da
Additional Information
Gene ID 214230
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~75 kDa of Pak6 in Western blot analysis. Reactivity to other species has not been tested.
Other Names Serine/threonine-protein kinase PAK 6; p21-activated kinase 6; PAK-6
Target/Specificity PAK6
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsPAK6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Pak6
Function Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Research Areas
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The PAK (p21-activated kinase) family of serine/threonine kinases plays an important role in multiple cellular processes, including cytoskeletal reorganization, MAPK signaling, apoptotic signaling, etc. Several mechanisms that induce PAK activation have been reported. Binding of Rac/cdc42 to the CRIB (or PBD) domain at the N-terminal region of PAK causes autophosphorylation and conformational change of PAK. More recently identified members PAK4, PAK5 and PAK6 have lower sequence similarity with PAK1-3 in the regulatory N-terminal region.

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$ 245.00
Cat# ABV10715
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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