|Calculated MW||28057 Da|
|Positive Control||Rat kidney tissue lysate|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Rat kidney tissue lysate can be used as a positive control.|
|Other Names||Complement factor D, 28 kDa adipocyte protein, C3 convertase protein, C3 convertase activator, Properdin factor D|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-Adipsin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Adipsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.|
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Provided below are standard protocols that you may find useful for product applications.
Adipsin is a serine protease secreted by adipose tissue, and it has also been found in monocytes/macrophages. Adipsin has been identified to be similar to complement Factor D. Adipsin cleaved complement Factor B when the later form complexed with activated complement component C3. Low level expression of Adipsin has been linked to obesity in mouse model s µggesting that defects in Adipsin is the result of this systemic disorder.
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