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AdipoR1 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q91VH1 |
| Other Accession | EDL39610 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42366 Da |
| Gene ID | 72674 |
|---|---|
| Positive Control | 3T3 cell lysate |
| Application & Usage | Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. 3T3 cell lysate can be used as a positive control. |
| Other Names | adiponectin receptor protein 1, progestin and adipoQ receptor family member I |
| Target/Specificity | AdipoR1 |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 200 µg (0.5 mg/ml) affinity purified rabbit anti-AdipoR1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | AdipoR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Adipor1 {ECO:0000312|MGI:MGI:1919924} |
|---|---|
| Function | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96A54} Note=Localized to the cell membrane and intracellular organelles {ECO:0000250|UniProtKB:Q96A54} |
| Tissue Location | Detected in brain and quadriceps muscle (at protein level) (PubMed:17327425). Widely expressed (PubMed:12802337). Expressed in heart, kidney, liver, lung, skeletal muscle, white adipose tissue, brown adipose tissue, aorta and spleen (PubMed:12802337, PubMed:24742672). Weakly expressed in brain and testis (PubMed:12802337). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The adiponectin receptors, ADIPOR1 and ADIPOR2 are receptors for globular and full-length adiponectin. These receptors mediate the increase of AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
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Discontinued
Cat# ABV10728-30
Size:
Ordering Information
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