|Calculated MW||42366 Da|
|Positive Control||3T3 cell lysate|
|Application & Usage||Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. 3T3 cell lysate can be used as a positive control.|
|Other Names||adiponectin receptor protein 1, progestin and adipoQ receptor family member I|
|Formulation||200 µg (0.5 mg/ml) affinity purified rabbit anti-AdipoR1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||AdipoR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.|
|Cellular Location||Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.|
|Tissue Location||Widely expressed. Expressed in heart, kidney, liver, lung, skeletal muscle and spleen. Weakly expressed in brain and testis.|
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Provided below are standard protocols that you may find useful for product applications.
The adiponectin receptors, ADIPOR1 and ADIPOR2 are receptors for globular and full-length adiponectin. These receptors mediate the increase of AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
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