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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AdipoR1 Antibody   

AdipoR1 Antibody

Rabbit Polyclonal Antibody

     
  • WB - AdipoR1 Antibody ABV10728
    Antibody. Western blot analysis of AdipoR1 with 3T3 cell lysate.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q91VH1
Other Accession EDL39610
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 42366 Da
Additional Information
Gene ID 72674
Positive Control 3T3 cell lysate
Application & Usage Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. 3T3 cell lysate can be used as a positive control.
Other Names adiponectin receptor protein 1, progestin and adipoQ receptor family member I
Target/Specificity AdipoR1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 200 µg (0.5 mg/ml) affinity purified rabbit anti-AdipoR1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAdipoR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Adipor1
Function Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337).
Cellular Location Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96A54} Note=Localized to the cell membrane and intracellular organelles {ECO:0000250|UniProtKB:Q96A54}
Tissue Location Detected in brain and quadriceps muscle (at protein level) (PubMed:17327425). Widely expressed (PubMed:12802337). Expressed in heart, kidney, liver, lung, skeletal muscle, white adipose tissue, brown adipose tissue, aorta and spleen (PubMed:12802337, PubMed:24742672). Weakly expressed in brain and testis (PubMed:12802337).
Research Areas
Citations (0)

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Background

The adiponectin receptors, ADIPOR1 and ADIPOR2 are receptors for globular and full-length adiponectin. These receptors mediate the increase of AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.

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$ 89.00
$ 245.00
Cat# ABV10728
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