|Reactivity||Human, Mouse, Rat|
|Calculated MW||97476 Da|
|Positive Control||Jurkat cell lysate, HeLa cell lysate|
|Application & Usage||The antibody can be used for Western blotting (0.5–4 µg/ml).|
|Other Names||hydroxymethylglutaryl-CoA reductase|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-HMG-CoA Reductase polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||HMG-CoA Reductase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
HMG-CoA reductase (HMGCR) is the rate-limiting enzyme for cholesterol biosynthesis. HMGCR is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Statin, a class of cholesterol-lowering dr µgs inhibits HMGCR by lowering plasma cholesterol.
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