|Reactivity||Human, Mouse, Rat|
|Calculated MW||128746 Da|
|Positive Control||Jurkat, Rat kidney, 3T3 cell lysates|
|Application & Usage||The antibody can be used for Western blotting (1–4 µg/ml).|
|Other Names||TSC1; TSC; KIAA0243; LAM; MGC86987|
|Formulation||200 µg (0.5 mg/ml) affinity purified rabbit anti-TSC1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||TSC1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.|
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Provided below are standard protocols that you may find useful for product applications.
Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle thro µgh its ability to integrate signals from nutrient levels and growth factors
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