|Calculated MW||27818 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been tested. Recombinant human BDNF can be used as a positive control.|
|Other Names||brain-derived neurotrophic factor, brain derived neurotrophic factor|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human BDNF polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||BDNF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.|
|Tissue Location||Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Human Brain-Derived Neurotrophic Factor (BDGF) is a potent neurotrophic factor that supports the growth and survivability of nerve and glial cells. BDNF protein is a 27.0 kDa dimer, formed by two identical 119 amino acid subunits held together by strong hydrophobic interactions. The antibody recognizes the mature form of BDNF at 14 kDa.
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