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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   GDNF Antibody   

GDNF Antibody

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48540
Other Accession BAA08660
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 23662 Da
Additional Information
Gene ID 14573
Application & Usage Western blotting (0.5-4 µg/ml). Based on researcher’s feedback, the antibody also works in immunoprecipitation (10-20 µg/ml), and Immunohistochemistry (10-20 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes GDNF of human, mouse, and rat origins. Jurkat cell lysate can be used as a positive control.
Other Names neurotrophic factor GDNF, GDNF, Glial cell line-derived neurotrophic factor, Astrocyte-derived trophic factor; ATF
Target/Specificity GDNF
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.2 mg/ml) protein A affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsGDNF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Gdnf
Function Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Cellular Location Secreted.
Tissue Location Expressed in both the central nervous system (CNS) and in non-CNS tissues. Expressed in a highly dynamic pattern in the anterior neuroectoderm during the early stages of neurogenesis between E7.5 and E10.5. Beginning at E10.5, expression begins in mesenchymal tissues of several organs including the digestive tract, kidney, testis, frontonasal mass, tooth primordium, tongue, mandible, whisker follicles, ear, eye, limb bud and in distinct regions of the brain. Also expressed in the heart, ileum, liver and muscle.
Research Areas
Citations (0)

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Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF is a glycosylated, disulfide-bonded homodimer. It promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. On the basis of these findings, it has been s µggested that GDNF may play a role in the treatment of Parkinson’s disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.

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$ 295.00
$ 89.00
Cat# ABV10827
(40 western blots)
Availability: 5-7days
Bulk Size
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