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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL-17F Antibody   

IL-17F Antibody

Rabbit Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96PD4
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 18045 Da
Additional Information
Gene ID 112744
Positive Control ELISA: Recombinant hIL-17F
Application & Usage 1) WB: Use 0.1-0.2 µg/ml. The detection limit for recombinant human IL-17F is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
2) ELISA: Use 0.5 - 2.0 µg/ml (100 µl/well antibody solution)
3) Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hIL-17F (50.0 ng/ml), a concentration of 0.9-1.2 µg/ml of this antibody is required.
Other Names IL17A/F, IL17 A/F, IL-17A/F, IL-17 A/F, IL17AF, IL-17, AF, Interleukin-17 A/F, Interleukin-17 AF
Target/Specificity IL-17A
Antibody Form Liquid
Appearance Liquid
Formulation A sterile filtered antibody solution in PBS, pH 7.2.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsIL-17F Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL17F
Function Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).
Cellular Location Secreted.
Tissue Location Expressed in activated, but not resting, CD4+ T-cells and activated monocytes
Research Areas
Citations (0)

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Background

IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.

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$ 245.00
Cat# ABV10834-50
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