|Application ||WB, E|
|Calculated MW||18045 Da|
|Positive Control||ELISA: Recombinant hIL-17F|
|Application & Usage||1) WB: Use 0.1-0.2 µg/ml. The detection limit for recombinant human IL-17F is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.|
2) ELISA: Use 0.5 - 2.0 µg/ml (100 µl/well antibody solution)
3) Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hIL-17F (50.0 ng/ml), a concentration of 0.9-1.2 µg/ml of this antibody is required.
|Other Names||IL17A/F, IL17 A/F, IL-17A/F, IL-17 A/F, IL17AF, IL-17, AF, Interleukin-17 A/F, Interleukin-17 AF|
|Formulation||A sterile filtered antibody solution in PBS, pH 7.2.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||IL-17F Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.|
|Tissue Location||Expressed in activated, but not resting, CD4+ T-cells and activated monocytes|
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Provided below are standard protocols that you may find useful for product applications.
IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
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