|Calculated MW||20140 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human IGF-II can be used as a positive control. Other applications have not been determined.|
|Other Names||IGF2, IGF-2, IGF 2, Insulin like growth factor-2, Insulin like growth factor 2|
|Formulation||100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-human IGF-II polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||IGF-II Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464).|
|Tissue Location||Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
IGF-II (Insulin-like Growth Factor-II) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types. Human IGF-II is a 7.5 kDa protein containing 67 amino acid residues.
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