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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   NGN2 Antibody (CT)   

NGN2 Antibody (CT)

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H2A3
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG1
Additional Information
Positive Control Western Blot: Rat brain tissue lysate
Application & Usage Western Blot: 1 - 2 µg/ml, ELISA. However, the optimal conditions should be determined individually.
Other Names Neurogenin-2, Neurog2, NGN-2, atonal homolog 4, atoh4, math4a, basic helix-loop-helix protein 8, bHLHa8
Target/Specificity NGN2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (1 mg/ml) in 1X PBS containing 1 mg/ml BSA, 50% glycerol and less than 0.02% sodium azide, pH 7.4.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsNGN2 Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ATOH4, BHLHA8, NGN2
Function Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981} EMBL; BC036847; AAH36847.1; -; mRNA EMBL; AF303002; AAG40770.1; -; Genomic_DNA CCDS; CCDS3698.1; - RefSeq; NP_076924.1; NM_024019.3 UniGene; Hs.744415; - ProteinModelPortal; Q9H2A3; - SMR; Q9H2A3; - BioGrid; 122020; 2 IntAct; Q9H2A3; 2 MINT; Q9H2A3; - STRING; 9606.ENSP00000317333; - iPTMnet; Q9H2A3; - PhosphoSitePlus; Q9H2A3; - BioMuta; NEUROG2; - DMDM; 60392832; - PaxDb; Q9H2A3; - PRIDE; Q9H2A3; - ProteomicsDB; 80519; - Ensembl; ENST00000313341; ENSP00000317333; ENSG00000178403 GeneID; 63973; - KEGG; hsa:63973; - UCSC; uc003ias.3; human CTD; 63973; - DisGeNET; 63973; - EuPathDB; HostDB:ENSG00000178403.3; - GeneCards; NEUROG2; - HGNC; HGNC:13805; NEUROG2 HPA; CAB012342; - MIM; 606624; gene neXtProt; NX_Q9H2A3; - OpenTargets; ENSG00000178403; - PharmGKB; PA31570; - eggNOG; ENOG410IQ4B; Eukaryota eggNOG; ENOG410XZ4C; LUCA GeneTree; ENSGT00680000099860; - HOGENOM; HOG000063655; - HOVERGEN; HBG101129; - InParanoid; Q9H2A3; - KO; K09082; - OMA; SDMDYWQ; - OrthoDB; EOG091G0PNH; - PhylomeDB; Q9H2A3; - TreeFam; TF315153; - SIGNOR; Q9H2A3; - GeneWiki; NEUROG2; - GenomeRNAi; 63973; - PRO; PR:Q9H2A3; - Proteomes; UP000005640; Chromosome 4 Bgee; ENSG00000178403; - CleanEx; HS_NEUROG2; - Genevisible; Q9H2A3; HS GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell GO; GO:0070888; F:E-box binding; ISS:UniProtKB GO; GO:0046983; F:protein dimerization activity; IEA:InterPro GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0030182; P:neuron differentiation; IEA:InterPro GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; ISS:UniProtKB GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW CDD; cd00083; HLH; 1 Gene3D;; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR032655; Ngn2 PANTHER; PTHR19290:SF105; PTHR19290:SF105; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 2: Evidence at transcript level; Activator; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 272 Neurogenin-2 /FTId=PRO_0000127400 DOMAIN 112 164 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} COMPBIAS 198 246 Ser-rich SEQUENCE 272 AA; 28621 MW; 57AB37CC4A9E15FC CRC64; MFVKSETLEL KEEEDVLVLL GSASPALAAL TPLSSSADEE EEEEPGASGG ARRQRGAEAG QGARGGVAAG AEGCRPARLL GLVHDCKRRP SRARAVSRGA KTAETVQRIK KTRRLKANNR ERNRMHNLNA ALDALREVLP TFPEDAKLTK IETLRFAHNY IWALTETLRL ADHCGGGGGG LPGALFSEAV LLSPGGASAA LSSSGDSPSP ASTWSCTNSP APSSSVSSNS TSPYSCTLSP ASPAGSDMDY WQPPPPDKHR YAPHLPIARD CI
Research Areas
Citations (0)

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Neurogenin-2 (NGN2) is a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. NGN2 is tho µght to work with Nurr1 to play a role in the differentiation and survival of midbrain dopaminergic neurons. It has also been s µggested for use in human embryonic neural progenitors as a graft for spinal cord injuries

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Cat# ABV10909-100
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