NGN2 Antibody (CT)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9H2A3 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG1 |
Calculated MW | 28621 Da |
Gene ID | 63973 |
---|---|
Positive Control | Western Blot: Rat brain tissue lysate |
Application & Usage | Western Blot: 1 - 2 µg/ml, ELISA. However, the optimal conditions should be determined individually. |
Other Names | Neurogenin-2, Neurog2, NGN-2, atonal homolog 4, atoh4, math4a, basic helix-loop-helix protein 8, bHLHa8 |
Target/Specificity | NGN2 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (1 mg/ml) in 1X PBS containing 1 mg/ml BSA, 50% glycerol and less than 0.02% sodium azide, pH 7.4. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | NGN2 Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NEUROG2 |
---|---|
Synonyms | ATOH4, BHLHA8, NGN2 |
Function | Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Neurogenin-2 (NGN2) is a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. NGN2 is tho µght to work with Nurr1 to play a role in the differentiation and survival of midbrain dopaminergic neurons. It has also been s µggested for use in human embryonic neural progenitors as a graft for spinal cord injuries
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