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Protein A Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P02976 |
| Other Accession | YP_498670 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56437 Da |
| Gene ID | 3919448 |
|---|---|
| Application & Usage | Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant Protein A can be used as a positive control. |
| Other Names | ProteinA, Protein A |
| Target/Specificity | Protein A |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti-Protein A polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | Protein A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | spa |
|---|---|
| Function | Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins (PubMed:2938951, PubMed:4163007, PubMed:10805799). In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. Acts directly as a pro-inflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A (By similarity). |
| Cellular Location | Secreted, cell wall; Peptidoglycan-anchor; Extracellular side. Secreted. Note=Cell wall anchoring is conferred by the LPXTG motif and following sequences (PubMed:1638631). Anchored by sortase A (PubMed:10427003). SpA from strains A676 and V-I is secreted whereas SpA from Cowan 1 and 8325-4 is mostly attached to the cell wall (Probable). Newly synthesized protein is deposited at 2-4 foci/cell and eventually is distributed in a ring around the cell (PubMed:17416657). |
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Protein A binds to the constant region of many species of immunoglobulin G. Protein A can be used to detect, quantify and purify IgG antibodies and antibody/antigen complexes. Protein A binds to all IgG subclasses from human and mouse species.
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If you have any additional inquiries please email technical services at tech@abcepta.com.
Discontinued
Cat# ABV10978-30
Size:
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