|Calculated MW||53864 Da|
|Application & Usage||The antibody recognizes C3aR expressed in leukocytes and in transfected cells using flow cytometry.|
|Other Names||C3a receptor-like, C3a anaphylatoxin chemotactic receptor, C3a anaphylatoxin chemotactic, C3a-R, C3AR|
|Formulation||100 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||C3aR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||AZ3B, C3R1, HNFAG09|
|Function||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues|
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Provided below are standard protocols that you may find useful for product applications.
C3a is an anaphylatoxin generated thro µgh activation of the complement C3. C3a is a potent chemoattractant for phagocytes, and it stimulates chemotaxis and other leukocyte functions. C3a binds to eosinophils, basophils, neutrophils, and differentiated U937 cells, that all express receptors for C3a on their cell surface. The C3a receptor has been cloned and shown to be a G protein-coupled receptor with seven putative transmembrane domains. This receptor is characterized for its large extracellular loop between the fourth and fifth transmembrane domains. The loop can be readily detected using the rabbit anti-C3a receptor antibody.
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