|Calculated MW||11936 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). Recombinant murine RELMα can be used as a positive control. However, the optimal conditions should be determined individually.|
|Other Names||Resistin-like alpha, Cysteine-rich secreted protein FIZZ1|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti- murine RELMα polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||RELM-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Fizz1, Himf, Pmng1|
|Function||Probable hormone. Plays a role in pulmonary vascular remodeling.|
|Tissue Location||Highest levels in adipose tissue.|
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RELM-alpha belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELM-alpha and RELM-beta are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELM-alpha and Resistin are secreted exclusively by adipocytes while RELM-beta is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELM-alpha are still unknown. Murine RELM-alpha is a 10.0 kDa monomeric protein containing 88 amino acid residues.
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