RELM-alpha Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9EP95 |
Other Accession | NP_065255 |
Reactivity | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 11936 Da |
Gene ID | 57262 |
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Application & Usage | Western blot analysis (0.5-4 µg/ml). Recombinant murine RELMα can be used as a positive control. However, the optimal conditions should be determined individually. |
Other Names | Resistin-like alpha, Cysteine-rich secreted protein FIZZ1 |
Target/Specificity | RELM-alpha |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) affinity purified rabbit anti- murine RELMα polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | RELM-alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Retnla |
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Synonyms | Fizz1, Himf, Pmng1 |
Function | Probable hormone. Plays a role in pulmonary vascular remodeling. |
Cellular Location | Secreted. |
Tissue Location | Highest levels in adipose tissue. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RELM-alpha belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The three known members of this family; Resistin, RELM-alpha and RELM-beta are 85-94 amino acid secreted proteins sharing a conserved C-terminal domain characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELM-alpha and Resistin are secreted exclusively by adipocytes while RELM-beta is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELM-alpha are still unknown. Murine RELM-alpha is a 10.0 kDa monomeric protein containing 88 amino acid residues.
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