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VEGF-D Antibody

Rabbit Polyclonal Antibody

  • WB - VEGF-D Antibody ABV11029
    Western blot analysis of VEGF-D using recombinant human VEGF-D (50 ng).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43915
Other Accession D89630
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 40444 Da
Additional Information
Gene ID 2277
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human VEGF-D can be used as a positive control. Other applications have not been determined.
Other Names VEGFD, VEGF D, Vascular endothelial growth factor D, c-fos-induced growth factor, FIGF
Target/Specificity VEGF-D
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti- VEGF-D polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsVEGF-D Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms VEGFD
Function Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
Cellular Location Secreted.
Tissue Location Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas
Research Areas
Citations (0)

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EGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. The recombinant VEGF-D as the immunogen was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.

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$ 245.00
$ 89.00
Cat# ABV11029
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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