|Calculated MW||47113 Da|
|Application & Usage||Western blotting (0.5-2 µg/ml). It detects the 14 kDa monomer, 28 kDa dimer, as well as the 58 kDa tetramer of human BMP-2. Recombinant human BMP-2 can be used as a positive control. Reactivity to other species has not been tested.|
|Other Names||BMP2, BMP-2, BMP 2, bone morphogenetic protein 2, BMP-2A, BMP2A , BMP 2A|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-BMP-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||BMP-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented thro µghout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF-beta superfamily are disulfide-linked dimmers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis. It is also expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary and small intestine.
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