|Reactivity||Human, Mouse, Rat|
|Calculated MW||49313 Da|
|Application & Usage||Western blotting (1-4 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||BMP7, BMP-7, BMP 7, bone morphogenetic protein 7, Osteogenic protein 1, OP-1|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human BMP-7 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||BMP-7 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.|
|Tissue Location||Expressed in the kidney and bladder. Lower levels seen in the brain|
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Provided below are standard protocols that you may find useful for product applications.
BMPs (bone morphogenetic proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented thro µghout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF-beta superfamily are disulfide-linked dimmers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair. BMP-7 has been indicated to induce cartilage formation.
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