|Calculated MW||24789 Da|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human PIGF can be used as a positive control.|
|Other Names||PIGF1, PIGF 1, PIGF-1, Phosphatidylinositol glycan biosynthesis class F, PIG F|
|Formulation||100 µg (0.5 mg/ml) antigen affinity purified rabbit anti-human PlGF polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol and 0.01% Thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||PlGF-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.|
|Cellular Location||Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin|
|Tissue Location||While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
PlGF-1(also called Placenta Growth Factor-1, PLGF, and PGF) is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PlGF-1 is expressed in placental tissues, colon and mammary carcinomas. It signals thro µgh the VEGFR-1/FLT1 receptor and stimulates endothelial cell proliferation and migration. Human PlGF-1 is a 29.7 kDa disulfide-linked homodimeric protein of two 131 amino acid polypeptide chains.
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