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GDF-3 Antibody

Rabbit Polyclonal Antibody

     
  • WB - GDF-3 Antibody ABV11061-30
    Western blot analysis using recombinant human GDF-3. Lane 1: 1μg; Lane 2: 250 ng
    detail
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9NR23
Other Accession AAM27000
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 41387 Da
Additional Information
Gene ID 9573
Application & Usage Western blot analysis (0.5-4 µg/ml). Other applications have not been determined.
Other Names GDF3, GDF 3, GDF-3, Growth differentiation factor 3, VG-1-related protein 2, Vgr2, Vgr 2
Target/Specificity GDF-3
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit anti-human GDF-3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol , 0.5 mg/ml BSA, and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsGDF-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GDF3
Function Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor CRIPTO (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and CRIPTO/Cripto (PubMed:21805089).
Cellular Location Secreted. Cytoplasm. Note=Mainly accumulated in the cytoplasm
Research Areas
Citations (0)
citation

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Background

GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type-2 diabetes. Anti-human GDF-3 polyclonal antibody contains 114 amino acids.

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Discontinued
Cat# ABV11061-30
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