|Calculated MW||41387 Da|
|Application & Usage||Western blot analysis (0.5-4 µg/ml). Other applications have not been determined.|
|Other Names||GDF3, GDF 3, GDF-3, Growth differentiation factor 3, VG-1-related protein 2, Vgr2, Vgr 2|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human GDF-3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol , 0.5 mg/ml BSA, and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||GDF-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto (By similarity). Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089).|
|Cellular Location||Secreted. Cytoplasm Note=Mainly accumulated in the cytoplasm|
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Provided below are standard protocols that you may find useful for product applications.
GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type-2 diabetes. Anti-human GDF-3 polyclonal antibody contains 114 amino acids.
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