|Calculated MW||53977 Da|
|Positive Control||Recombinant human MMP-3|
|Application & Usage||Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually.|
|Other Names||Stromelysin-1, SL-1, Matrix metalloproteinase-3, MMP-3|
|Formulation||100 µg (0.5 mg/ml) affinity purified rabbit anti-human MMP-3 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5mM EDTA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||MMP-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Proteins of the matrix metalloprotease (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling as well as disease processes such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
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