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USP3 Antibody

Rabbit Polyclonal Antibody

  • WB - USP3 Antibody ABV11135
    WB of various cell lysates with USP3 pAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y6I4
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 58897 Da
Additional Information
Gene ID 9960
Positive Control Western Blot: Various cell lysates
Application & Usage Western blot: 1:500 – 1:1000 dilution. However, the optimal conditions should be determined individually.
Other Names USP3, MGC129878, MGC129879, SIH003, UBP
Target/Specificity USP3
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsUSP3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name USP3
Function Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Cellular Location Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin
Tissue Location Expressed in all tissues examined, with strongest expression in pancreas
Research Areas
Citations (0)

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Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzymes (DUB) action. There are five DUB subfamilies including the USP, UCH, OTU, MJD, and JAMM enzymes. USP3 (ubiquitin specific peptidase 3), also known as UBP or SIH003, is a 520 amino acid protein that contains one UBP­type zinc finger and belongs to the peptidase C19 family. Expressed ubiquitously with highest levels present in pancreas, USP3 catalyzes the conversion of a ubiquitin C­terminal thioester to a free ubiquitin and a thiol. The gene encoding USP3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome.

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$ 335.00
Cat# ABV11135
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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