KAT8 Antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q9H7Z6 |
Other Accession | NP_115564 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52403 Da |
Gene ID | 84148 |
---|---|
Positive Control | Western Blot: HeLa cell lysates |
Application & Usage | Western blot: 1:500 – 1:1000 |
Other Names | MOF, hMOF, MYST1, ZC2HC8, KAT8 |
Target/Specificity | KAT8 |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3 |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | KAT8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | KAT8 |
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Synonyms | MOF, MYST1 |
Function | Histone acetyltransferase which may be involved in transcriptional activation (PubMed:12397079, PubMed:22020126). May influence the function of ATM (PubMed:15923642). As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:22020126). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852, PubMed:22547026). That activity is less specific than the one of the MSL complex (PubMed:20018852, PubMed:22547026). Can also acetylate TP53/p53 at 'Lys-120'. |
Cellular Location | Nucleus. Chromosome |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetylCoAbinding site, a chromodomain typical of proteins which bind histones, and a C2HCtype zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [Provided by RefSeq, Feb 2012].
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