|Reactivity||Human, Mouse, Rat|
|Calculated MW||52403 Da|
|Positive Control||Western Blot: HeLa cell lysates|
|Application & Usage||Western blot: 1:500 – 1:1000|
|Other Names||MOF, hMOF, MYST1, ZC2HC8, KAT8|
|Formulation||100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||KAT8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.|
|Cellular Location||Nucleus. Chromosome|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetylCoAbinding site, a chromodomain typical of proteins which bind histones, and a C2HCtype zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [Provided by RefSeq, Feb 2012].
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