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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Thioredoxin 1 Antibody (3A1)   

Thioredoxin 1 Antibody (3A1)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43396
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG 1
Clone Names 3A1
Calculated MW 32251 Da
Additional Information
Gene ID 9352
Positive Control WB analysis of cell lysates.
Application & Usage Western blot: 1:1000, IP: 1-2 µl, ELISA.
Other Names TXN, TRX, TRX1.
Target/Specificity Thioredoxin 1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsThioredoxin 1 Antibody (3A1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXNL1
Synonyms TRP32, TXL, TXNL
Function Active thioredoxin with a redox potential of about -250 mV.
Cellular Location Cytoplasm. Nucleus. Note=At least 85% of the cellular TXNL1 is proteasome-associated
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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The mammalian thioredoxin reductases (TrxRs) are a family of seleno-cysteine containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate seleno-cysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55 – 58 kDa in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena. TrxR1 plays a central role as a glucosyl donor in cellular metabolic pathways.

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$ 325.00
Cat# ABV11159
(40 western blots)
Availability: 5-7days
Bulk Size
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