|Application ||E, IP|
|Clone Names||Clone 2B3|
|Calculated MW||56257 Da|
|Positive Control||WB and IP: HeLa cell lysate|
|Application & Usage||IP: 1-2 µl, ELISA.|
|Other Names||GSR, GLUR, GRD1|
|Formulation||100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Glutathione Reductase Antibody (Clone 2B3) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Maintains high levels of reduced glutathione in the cytosol.|
|Cellular Location||Isoform Mitochondrial: Mitochondrion.|
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Provided below are standard protocols that you may find useful for product applications.
Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG). In most eukaryotic cells, GR maintains the ratio of [GSH]/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
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