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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Glutathione Reductase Antibody (Clone 2B3)   

Glutathione Reductase Antibody (Clone 2B3)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00390
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1
Clone Names Clone 2B3
Calculated MW 56257 Da
Additional Information
Gene ID 2936
Positive Control WB and IP: HeLa cell lysate
Application & Usage IP: 1-2 µl, ELISA.
Other Names GSR, GLUR, GRD1
Target/Specificity Glutathione Reductase
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % sodium azide, and 50 % glycerol
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsGlutathione Reductase Antibody (Clone 2B3) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GSR
Synonyms GLUR, GRD1
Function Maintains high levels of reduced glutathione in the cytosol.
Cellular Location Isoform Mitochondrial: Mitochondrion.
Research Areas
Citations (0)

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Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG). In most eukaryotic cells, GR maintains the ratio of [GSH]/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.

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$ 325.00
Cat# ABV11174
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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