|Reactivity||Human, Mouse, Rat|
|Calculated MW||26739 Da|
|Application & Usage||Western blot: 1:200|
|Other Names||Chromatin-associated protein swi6|
|Formulation||100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2|
|Handling||The antibody solution should be gently mixed before use.|
|Reconstitution & Storage||-20 °C|
|Precautions||Swi6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.|
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Provided below are standard protocols that you may find useful for product applications.
Swi6 protein of fission yeast is a functional and structural homolog of HP1 (Heterochromatin Protein 1) of animals and is involved in the formation of heterochromatin structure by binding to centromere, telomere and silent mating-type locus. It is also involved in silencing the genes and sister chromatid cohesion by binding to histone H3 methylated at Lys9 and the cohesin subunit Psc3. It is also involved in the repression of the silent mating-type loci MAT2 and MAT3. It may compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes.
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