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>   home   >   Products   >   Primary Antibodies   >   BRD3-BD2 Antibody   

BRD3-BD2 Antibody

Rabbit Polyclonal Antibody

  • WB - BRD3-BD2 Antibody ABV11213
    Western blot of BRD3-BD2 antibody. Lane 1: Recombinant protein 10 ng. Lane 2: Recombinant protein 50 ng
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15059
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 79542 Da
Additional Information
Gene ID 8019
Positive Control Western Blot: Recombinant protein
Application & Usage Western blot: 1-4 µg/ml.
Other Names KIAA0043, RING3L
Target/Specificity BRD3-BD2
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µg or 30 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsBRD3-BD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BRD3
Synonyms KIAA0043, RING3L
Function Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.
Cellular Location Nucleus. Note=Detected on chromatin.
Tissue Location Ubiquitous.
Citations (0)

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The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD3 binds hyper-acetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. It regulates transcription by promoting the binding of the transcription factor GATA1 to its targets and transcription of the CCND1 gene. A chromosomal aberration involving BRD3 was found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people.

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$ 295.00
$ 89.00
Cat# ABV11213
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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