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Cyr61/CCN1 Antibody (Clone 466305)

Rat Monoclonal Antibody

  • IHC - Cyr61/CCN1 Antibody (Clone 466305) ABV11246-50
    Cyr61/CCN1 in Mouse Trigeminal Ganglia. Cyr61/CCN1 was detected in perfusion fixed frozen sections of mouse trigeminal ganglia using 25 μg/mL Cyr61/CCN1 Antibody O/N at 4 °C. Tissue was stained with the Anti-Rat HRP-DAB Cell & Tissue Staining Kit and counterstained with hematoxylin (blue).
  • WB - Cyr61/CCN1 Antibody (Clone 466305) ABV11246-50
    Detection of Mouse Cyr61 by Western Blot. Western blot shows lysates of mouse brain tissue (negative control) and mouse heart tissue. PVDF membrane was probed with 2 μg/mL of Cyr61/CCN1 Antibody followed by HRP-conjugated Anti-Rat IgG Secondary Antibody Specific bands were detected for Cyr61 (at approximately 50 kDa) and cleaved Cyr61 (at approximately 25 kDa).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P18406
Host Rat
Clonality Monoclonal
Isotype Rat IgG2B
Clone Names 466305
Calculated MW 41709 Da
Additional Information
Gene ID 16007
Positive Control Western blot: mouse heart tissue, IHC: mouse trigeminal ganglia.
Application & Usage WB: 2 µg/ml, IHC: 8-25 µg/ml.
Other Names CCN1, G1G1, IGFBP-10
Target/Specificity Cyr61/CCN1
Antibody Form Liquid
Appearance Lyophilized powder
Formulation Lyophilized from a 0.2 µm filtered solution in PBS with trehalose.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsCyr61/CCN1 Antibody (Clone 466305) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Cyr61
Synonyms Ccn1, Igfbp10
Function Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). Down- regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).
Cellular Location Secreted.
Tissue Location Low in kidney, adrenal gland, testes, brain, and ovary, moderate in heart, uterus, and skeletal muscle, highest in lung
Research Areas
Citations (0)

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Cyr61 is a member of angiogenic and vasculogenic regulators designated CCN proteins, which includes CTGF, Cyr61 homolog, Fisp2. Cyr61 functions as an angiogenic inducer, stimulating cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Elevated expression of Cyr61 is observed during vessel growth, wound healing and chondrocyte differentiation.

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$ 375.00
Cat# ABV11246-50
Availability: 5-7days
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