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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   ACHE Antibody (NT)   

ACHE Antibody (NT)

Rabbit Polyclonal Antibody

  • WB - ACHE Antibody (NT) ABV11256
    ACHE Antibody (N-term) western blot analysis in Jurkat, Raji, Y79 cell line lysates (35 μg/lane).This demonstrates the ACHE antibody detected the ACHE protein (arrow).
  • IHC - ACHE Antibody (NT) ABV11256
    Formalin-fixed and paraffin-embedded human brain tissue reacted with ACHE antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • IF - ACHE Antibody (NT) ABV11256
    Confocal immunofluorescent analysis of ACHE Antibody (N-term) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
  • FC - ACHE Antibody (NT) ABV11256
    ACHE Antibody (N-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram) .FITC-conjugated goat-anti-rabbit secondary antibody was used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P22303
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 67796 Da
Additional Information
Gene ID 43
Positive Control Western blot: Jurkat, Raji and Y79 cell lysate, IHC: human brain tissue, IF: NCI-H460 cells, FACS: NCI-H460 cells
Application & Usage Western blot: ~1:1000, FACS: ~1:10–1:50, IHC: ~1:10-1:50, IF: 1:10-1:50.
Other Names ACHE; Acetylcholinesterase
Target/Specificity ACHE
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsACHE Antibody (NT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Cellular Location Cell junction, synapse Secreted. Cell membrane; Peripheral membrane protein Isoform H: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
Tissue Location Isoform H is highly expressed in erythrocytes.
Research Areas
Citations (0)

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Acetylcholinesterase (AChE) hydrolyzes acetylcholine at synaptic junctions. Alternative mRNA splicing gives rise to three forms of AChE. It plays a role in neuronal apoptosis. The T form, also known as the asymmetric form, is soluble and is present in synapses. The H form is also known as the globular form and is present on the outer surfaces of cell membranes. The R form is not known to be a functional species. AChE globular form subunits are GPI-anchored to cell membranes and asymmetric subunits are anchored to basal lamina components by a collagen tail. The catalytic subunits of AChE are oligomers composed of disulfide-linked homodimers. The loss of AChE from cholinergic and noncholinergic neurons in the brain is seen in patients with Alzheimer’s disease. However, AChE activity is increased around amyloid plaques, which may be due to a disturbance in calcium homeostasis involving the opening of L-type voltage-dependent calcium channels.

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$ 245.00
Cat# ABV11256
(40 western blots)
Availability: 5-7days
Bulk Size
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