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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   AKR1A1 Antibody (CT)   

AKR1A1 Antibody (CT)

Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14550
Reactivity Human, Mouse, Rat, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 36573 Da
Additional Information
Gene ID 10327
Positive Control Western blot: Y79, 293 cell line lysates, IHC: human hepatocarcinoma
Application & Usage Western blot: ~1:1000, IHC: ~1:10 – 1:50
Other Names AKR1A1; ALDR1; ALR; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Aldo-keto reductase family 1 member A1
Target/Specificity AKR1A1
Antibody Form Liquid
Appearance Colorless liquid
Formulation 100 µl of antibody in PBS with 0.09% (W/V) sodium azide
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsAKR1A1 Antibody (CT) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AKR1A1
Synonyms ALDR1, ALR
Function Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Tissue Location Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung
Research Areas
Citations (0)

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AKR1A1 (aldo-keto reductase family 1 member A1), also known as ALR (aldehyde reductase), DD3 (dihydrodiol dehydrogenase 3) or ALDR1 (alcohol dehydrogenase), is a widely and abundantly expressed member of the aldo-keto reductase (AKR) family of proteins. Members of the AKR family are soluble NADPH-dependent oxidoreductases. They play important roles in the metabolism of drugs, carcinogens and reactive aldehydes. AKR1A1 exists as a monomer and catalyzes the reduction of xenobiotic and biogenic aldehydes and ketones to their corresponding alcohols. In particular, AKR1A1 efficiently catalyzes medium-chain and aromatic aldehydes. AKR1A1 participates in the biosynthetic pathways of cholesterol and triglyceride and plays a role in the activation of polycyclic aromatic hydrocarbons (PAHs).

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$ 245.00
Cat# ABV11288
(40 western blots)
Availability: 5-7days
Bulk Size
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