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JMJD2b polyclonal antibody
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | O94953 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 121897 Da |
| Gene ID | 23030 |
|---|---|
| Positive Control | Western blot: HeLa cells, ELISA: Peptides, IF: HeLa cells. |
| Application & Usage | Western Blot: 1:1000, ELISA: 1:200, IF: 1:200. |
| Other Names | JHDM3b, KDM4b |
| Target/Specificity | JMJD2b |
| Antibody Form | Liquid |
| Appearance | Colorless liquid |
| Formulation | In PBS with 0.05% (W/V) sodium azide. |
| Handling | The antibody solution should be gently mixed before use. |
| Reconstitution & Storage | -20 °C |
| Background Descriptions | |
| Precautions | JMJD2b polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KDM4B |
|---|---|
| Synonyms | JHDM3B, JMJD2B, KIAA0876 |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys- 20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
JMJD2b belongs to the JMJD2 family of histone demethylases which play an important role in the establishment of the histone code. JMJD2b specifically demethylates the trimethylated K9 of histone H3. It is not able to demethylate K4, K27 and K36 of histone H3, nor K20 of histone H4.
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