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Jarid1b polyclonal antibody

Rabbit Polyclonal Antibody

  • E - Jarid1b polyclonal antibody ABV11388
    To determine the titer, an ELISA was performed using a serial dilution of the antibody. The wells were coated with the peptide used for immunization of the rabbit. By plotting the absorbance against the antibody dilution, the titer of the antibody was estimated to be 1:2,200.
  • WB - Jarid1b polyclonal antibody ABV11388
    Western blot was performed on whole cell lysates from mouse fibroblasts (NIH3T3) and embryonic stem cells (E14Tg2a) with the antibody diluted 1:500 in BSA/PBS-Tween. The molecular weight marker (in kDa) is shown on the left; the location of the protein of interest (expected size: 179 kDa) is indicated on the right.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UGL1
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 175658 Da
Additional Information
Gene ID 10765
Positive Control Western blot: NIH3T3 and embryonic stem cells, ELISA: Peptides.
Application & Usage Western Blot: 1:500, ELISA: 1:100 – 1:200.
Other Names CT31, PLU1, PUT1, RBBP2H1, RBP2-like
Target/Specificity Jarid1b
Antibody Form Liquid
Appearance Colorless liquid
Formulation In PBS with 0.05% (W/V) sodium azide.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage -20 °C
Background Descriptions
PrecautionsJarid1b polyclonal antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KDM5B
Synonyms JARID1B, PLU1, RBBP2H1
Function Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:12237901}
Tissue Location Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).
Citations (0)

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JARID1b is a histone demethylase which specifically demethylates mono-, di, and trimethylated lysine 4 of histone H3. It acts as a transcriptional repressor for the tumor suppressor genes BRCA1 and HOXA5 and has been associated with breast cancer development. In contrast, in melanoma JARID1b itself may function as a tumor suppressor.

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$ 185.00
Cat# ABV11388
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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