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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD11b FITC Monoclonal Antibody (Clone ICRF44)   

CD11b FITC Monoclonal Antibody (Clone ICRF44)

Mouse Monoclonal Antibody

  • FC - CD11b FITC Monoclonal Antibody (Clone ICRF44) ABV11469
    Human peripheral blood lymphocytes were stained with FITC ICRF44 with relevant isotype control in Red.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P11215
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1, Kappa
Clone Names ICRF44
Calculated MW 127179 Da
Additional Information
Gene ID 3684
Positive Control FACS: Human PMBCs
Application & Usage Flow (Cell Surface): 5 µl/1x10^6 cells, Volume per test: 5 µl (1 µg).
Other Names CD11b
Target/Specificity CD11b
Antibody Form Liquid
Appearance Colorless liquid
Formulation Phosphate-buffered aqueous solution pH 7.2, ≤0.09% Sodium azide, may contain carrier protein/stabilizer.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage 4°C
Background Descriptions
PrecautionsCD11b FITC Monoclonal Antibody (Clone ICRF44) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD11B, CR3A
Function Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Predominantly expressed in monocytes and granulocytes
Research Areas
Citations (0)

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CD3 (T3), a complex T cell marker, is known to associate noncovalently with the a/b or g/z heterodimer of the T cell antigen receptor (TCR) to form the most complex transmembrane (TM) receptor structures. CD3 is specially engaged in antigen recognition and is known to play an important role in mediating signals that are critical for T cell development in the thymus, proliferation, and induction of T cell-mediated immune responses against infectious agents and also in the differentiation of T cells into effector and memory populations. CD3 usually expresses in the cytoplasm of prothymocytes, and on the surface of about 95% of thymocytes, but cytoplasmic CD3 is lost as the cells differentiate into medullary thymocytes. Apart from its role as an important marker in the classification of malignant lymphomas and lymphoid leukemia, CD3 can also be useful for the identification of T cells in celiac disease, lymphocytic colitis and colorectal carcinomas associated with loss of a mismatch repair protein. CD3 indirectly plays an important role in immunomodulation whereas the anti-CD3 antibody may be used in in vitro Treg assays to generate effector T cells. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. CD3 enhances the antigen recognition by signal transduction. The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

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$ 115.00
$ 295.00
Cat# ABV11469
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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