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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD28 FITC Monoclonal Antibody (Clone CD28.2)   

CD28 FITC Monoclonal Antibody (Clone CD28.2)

Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10747
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse IgG1, Kappa
Clone Names CD28.2
Calculated MW 25066 Da
Additional Information
Gene ID 940
Positive Control FACS: Human peripheral blood lymphocytes
Application & Usage Flow (Cell Surface): 5 µl/1x10^6 cells, Volume per test: 5 µl (0.5 µg).
Other Names CD28
Target/Specificity CD28
Antibody Form Liquid
Appearance Colorless liquid
Formulation Phosphate-buffered aqueous solution pH 7.2, ≤0.09% Sodium azide, may contain carrier protein/stabilizer.
Handling The antibody solution should be gently mixed before use.
Reconstitution & Storage 4°C
Background Descriptions
PrecautionsCD28 FITC Monoclonal Antibody (Clone CD28.2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD28
Function Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in T-cells and plasma cells, but not in less mature B-cells
Research Areas
Citations (0)

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CD28 (Cluster of Differentiation 28) is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some sub regions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.

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$ 115.00
$ 255.00
Cat# ABV11473
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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