|Application ||WB, Neut|
|Calculated MW||32509 Da|
|Other Names||TNFSF10, TRAIL-PEN, TL2, Apo-2L, CD253, APO2L|
|Formulation||100 µg (0.5 mg/ml) affinity purified, rabbit anti-TRAIL polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||TRAIL Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Widespread; most predominant in spleen, lung and prostate|
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TRAIL (TNF-related apoptosis-inducing ligand), a member of the TNF ligand family, is a type II membrane protein and expressed in a variety of human tissues. Two death domains containing receptors DR4 and DR5 have been identified as the receptors for TRAIL and two decoy receptors designated DcR1 and DcR2 inhibit TRAIL function. The multiple receptors s µggest a complex role for regulation of signaling by the cytokine. TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
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