|Calculated MW||27716 Da|
|Other Names||Granzyme B, 184.108.40.206, C11, CTLA-1, Cathepsin G-like 1, CTSGL1, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, Fragmentin-2, Granzyme-2, Human lymphocyte protein, HLP, SECT, T-cell serine protease 1-3E, GZMB, CGL1, CSPB, CTLA1, GRB|
|Formulation||Concentrated mouse tissue culture supernatant (1 mg/ml) in PBS containing 30% glycerol, 0.1% BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||Granzyme B Monoclonal Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CGL1, CSPB, CTLA1, GRB|
|Function||This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.|
|Cellular Location||Cytoplasmic granule. Note=Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells|
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Provided below are standard protocols that you may find useful for product applications.
The Lytic enzymes of cytotoxic lymphocytes seem to be contained within lysosome-like granules found in the cytoplasm. These granules contain perforin, a membrane pore-forming protein, and a family of serine proteases (granzymes). Granzyme B, a 32 kDa protein, is a serine Aspase associated with the granules of Natural Killer (NK) cells. Granzyme B seems to be able to elicit cell death, perhaps by activating an endogenous pathway of programmed cell death.
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