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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   uPAR Antibody   

uPAR Antibody

Purified Goat Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IP, Neut
Primary Accession Q03405
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Goat IgG
Calculated MW 36978 Da
Additional Information
Gene ID 5329
Other Names Urokinase plasminogen activator receptor , PLAUR , uPAR , CD87 , MO3 , UPAR , URKR, Urokinase plasminogen activator surface receptor; U-PAR; uPAR; Monocyte activation antigen Mo3; CD_antigen, CD87
Target/Specificity uPAR
Format 100 µg (0.5 mg/ml) purified goat polyclonal antibody in 1X phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal..
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsuPAR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MO3, UPAR
Function Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
Cellular Location Cell membrane. Cell projection, invadopodium membrane. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner Isoform 2: Secreted.
Tissue Location Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain
Research Areas
Citations (0)

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uPAR (Urokinase plasminogen activator receptor) is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum β-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.

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$ 295.00
Cat# ABV11531
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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