|Application ||WB, IP|
|Calculated MW||116070 Da|
|Other Names||TAOK1, TAO kinase 1, MARKK, Microtubule affinity regulating kinase kinase, MAP3K16, PSK2, TAO1|
|Formulation||100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.|
|Handling||The antibody solution should be gently mixed before use.|
|Precautions||TAOK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1361, MAP3K16, MARKK|
|Function||Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.|
|Tissue Location||Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene
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