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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TAOK1 Antibody   

TAOK1 Antibody

Purified Rabbit Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7L7X3
Other Accession NP_065842.1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 116070 Da
Additional Information
Gene ID 57551
Other Names TAOK1, TAO kinase 1, MARKK, Microtubule affinity regulating kinase kinase, MAP3K16, PSK2, TAO1
Target/Specificity TAOK1
Format 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsTAOK1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAOK1
Synonyms KIAA1361, MAP3K16, MARKK
Function Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle.
Research Areas
Citations (0)

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Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene

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$ 265.00
Cat# ABV11557
(40 western blots)
Availability: 5-7days
Bulk Size
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