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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Rabex-5 Antibody   

Rabex-5 Antibody

Purified Rabbit Polyclonal Antibody

  • WB - Rabex-5 Antibody ABV11566
    Western blot of 3T3 lysate with Rabex-5.
  • WB - Rabex-5 Antibody ABV11566
    Western blot of Rat kidney lysate with Rabex-5
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UJ41
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 79371 Da
Additional Information
Gene ID 27342
Other Names Rab5 GDP/GTP exchange factor
Target/Specificity Rabex-5
Format 100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2
Handling The antibody solution should be gently mixed before use.
Background Descriptions
PrecautionsRabex-5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RABEX5
Function Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).
Cellular Location Cytoplasm. Early endosome. Recycling endosome
Research Areas
Citations (0)

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Rabex-5, also called RabGEF1 and RAP1, was identified as a guanine nucleotide exchange factor (GEF) for Rab5, a member of the Ras superfamily of small Rab GTPases (1). Rabex-5 generates the GTP-bound active form of Rab5 and forms a tight association with its effector protein Rabaptin-5. This complex localizes to endosomal membranes where it functions as a key regulator of vesicular trafficking during early endocytosis. Rabex-5 is also monoubiquitinated and has ubiquitin ligase activity that regulates its recruitment to early endosomes. The conformational change between Rab5 GTP/GDP states is essential for its biological function as a rate limiting regulator at multiple steps during endocytosis. Through its control of endosomal trafficking and endocytosis, Rabex-5 has been shown to negatively regulate NGF-mediated neurite outgrowth as well as FcεRI-dependent mast cell activation.

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$ 265.00
Cat# ABV11566
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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